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目的观察岩舒注射液在中晚期大肠癌化疗中的辅助作用。方法64例中晚期大肠癌患者随机分为化疗组(对照组)和化疗联合岩舒组(试验组),其中试验组32例奥沙利铂130mg/m2+5%GS250ml静脉滴注,第1天;亚叶酸钙(CF)100mg+5%葡萄糖注射液250ml,静脉滴注第1～5天;氟尿嘧啶0.5g(5-Fu)+5%GS250ml静脉滴注,第1～20天常规给予5-HT3受体抑制剂止吐,21d为1周期。对照组32例,化疗方法同治疗组。结果试验组有效率为65.6%,对照组有效率为40.6%治疗组有效率明显高于对照组,差异有统计学意义(P<0.05);对照组白细胞减少为78.1%,高于试验组的62.5%。结论岩舒注射液联合化疗可显著提高化疗疗效,增强机体免疫功能,改善患者的生存质量,并可降低化疗药物对骨髓的抑制作用。
Objective To observe the auxiliary effect of Yan Shu injection in the chemotherapy of advanced colorectal cancer. Methods 64 patients with advanced colorectal cancer were randomly divided into chemotherapy group (control group) and chemotherapy combined with Yan Shu group (experimental group), in which 32 patients in experimental group were given intravenous drip of oxaliplatin 130mg / m2 + 5% GS250ml, Day; 5 to 10 folic acid calcium (CF) 100mg + 5% glucose injection 250ml intravenous drip 1 to 5 days; 5-fluorouracil 0.5g (5-Fu) +5% GS250ml intravenous drip, -HT3 receptor inhibitor antiemetic, 21d for a cycle. Control group of 32 cases, chemotherapy with the treatment group. Results The effective rate was 65.6% in the experimental group and 40.6% in the control group, and the effective rate in the treatment group was significantly higher than that in the control group (P <0.05). The leukopenia in the control group was 78.1% 62.5%. Conclusion Yanshu injection combined with chemotherapy can significantly improve the efficacy of chemotherapy, enhance immune function, improve the quality of life of patients, and reduce the inhibitory effect of chemotherapy drugs on bone marrow.