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目的:评价血必净辅助治疗大肠癌合并肠梗阻术后患者脓毒症的临床疗效.方法:收集我院ICU病房内诊断为脓毒症的大肠癌合并肠梗阻术后患者36例,随机分为治疗组19例和对照组17例.对照组给予常规抗炎治疗;治疗组在此基础上加用血必净注射液100mL,2次/d,疗程7d.检测肿瘤坏死因子(TNF-α)、白介素(IL-6)、急性生理和慢性健康状况评分Ⅱ(APACHE Ⅱ)、白细胞及中性粒细胞百分比.结果:治疗组第7天TNF-α、IL-6、APACHE Ⅱ、白细胞及中性粒细胞百分比与对照组比较(325.33±168.49ng/L vs 432.34±154.89ng/L,26.32±13.65ng/L vs 35.77±15.86ng/L,7.3±1.3×109/L vs 10.2±2.2×109/L,76.4%±10.3% vs 84.8%±8.0%,8.8±4.5 vs 13.3±4.4,均P<0.05),有统计学差异;治疗组患者最终死亡率较对照组显著下降(0.05% vs 0.30%,P<0.05),差别有统计学意义.结论:大肠癌合并肠梗阻术后脓毒症患者在常规抗炎基础上加用血必净注射液,改善症状,降低死亡率.
To evaluate the clinical efficacy of Xuebijing in adjuvant treatment of sepsis in patients with colorectal cancer and intestinal obstruction.Methods: Thirty-six patients with colorectal cancer and intestinal obstruction who were diagnosed as sepsis in ICU ward of our hospital were randomly divided 19 cases in the treatment group and 17 cases in the control group.The control group was given conventional anti-inflammatory treatment.The treatment group was treated with Xuebijing injection 100ml twice daily for 7 days.The levels of tumor necrosis factor-α ), Interleukin (IL-6), acute physiology and chronic health score Ⅱ (APACHE Ⅱ), percentage of leukocytes and neutrophils.Results: The levels of TNF-α, IL-6, APACHE Ⅱ, The percentage of neutrophils was (325.33 ± 168.49 ng / L vs. 432.34 ± 154.89 ng / L, 26.32 ± 13.65 ng / L vs 35.77 ± 15.86 ng / L, 7.3 ± 1.3 × 109 / L vs 10.2 ± 2.2 × (P <0.05), and the difference was statistically significant. The final mortality rate in the treatment group was significantly lower than that in the control group (0.05% vs 109 / L, 76.4% ± 10.3% vs 84.8% ± 8.0%, 8.8 ± 4.5 vs 13.3 ± 4.4 0.30%, P <0.05), the difference was statistically significant.Conclusion: Sepsis patients with colorectal cancer complicated with ileus were treated with Xuebijing injection on the basis of conventional anti-inflammatory, And reduce mortality.