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本研究的目的是测定地方性甲状腺肿流行区10年内(1975～1984年)总的甲状腺毒症及其两种主要类型的发病率。 研究方法 调查地区Jamtland位于瑞典中部,面积50000平方公里,人口134000,为地甲肿流行区。调查期间人口稳定,年龄结构也无大变化。惟当地大于60岁的老年人口比例(26%)略高于全国平均水平(22%)。人口中1/3居住于该地区中心部位的城市,2/3居住在周围的乡村。所有居民均在当地唯一的一所综合医院就诊。凡怀疑有甲状腺毒症的病人都作进一步的检查确诊(包括临床检查和T_3、T_4、TSH放免测定)。发现T_3和/或T_4增高者,在确诊为甲状腺毒症前都作重复测定。确诊后的病人,根据体格检查、放射性碘摄取试验(包括放射性碘或锝的扫描)以及组织病理学检查(手术病人),分为弥漫性甲状腺肿(TDG)和毒性结节性甲状腺肿两型(TNG),单个毒性甲状腺瘤包括在TNG内。发病率呈Poisson分布,发病率间的统计学差异按Cox法检验。
The purpose of this study was to determine the overall incidence of thyrotoxicosis and its two major types of disease in endemic goitre within 10 years (1975-1984). Research Methods Survey area Jamtland is located in central Sweden, an area of 50,000 square kilometers, population 134,000, for the endemic area of goiter. During the survey, the population was stable with no major change in age structure. However, the proportion of the elderly population aged over 60 (26%) is slightly above the national average (22%). One third of the population live in cities in the center of the region and two-thirds live in surrounding villages. All residents are treated at the only general hospital in the area. All patients suspected of having thyrotoxicosis are further diagnosed (including clinical examination and T_3, T_4, TSH radioimmunoassay). Found T_3 and / or T_4 increased, were diagnosed as thyrotoxicosis before making repeated measurements. After diagnosis, the patients were divided into diffuse goiter (TDG) and toxic nodular goiter according to the physical examination, radioactive iodine intake test (including radioactive iodine or technetium scan) and histopathological examination (surgical patients) (TNG), a single toxic thyroid tumor is included in the TNG. The incidence was Poisson distribution, the statistical difference between the incidence of Cox test.