癫痫的产生是由于兴奋作用增强,抑制作用减弱或两者兼有之。苔藓状纤维发芽致局部兴奋性环路形成机制、突触抑制作用减弱机制包括GABA能抑制性神经元选择性缺失及“篮状细胞休眠学说”分别从兴奋、抑制两方面阐述了颞叶癫痫发病机理。近年研究表明苔藓状纤维发芽使颗粒细胞兴奋性增高的同时,突触后GABA_A受体亦发生功能变化,易被MF末梢释放Zn~(2+)阻断,导致GABA抑制作用减弱,由此提出苔藓状纤维发芽/Zn~(2+)敏感性GABA_A受体机制,成为学术界研究的热点。 Epilepsy is due to increased excitatory effects, diminished suppressive effects, or both. Moss-like fiber germination caused by local excitatory loop formation mechanism, the mechanism of synaptic inhibition weakened, including GABA can inhibit the selective deletion of neurons and the “basal cell dormancy theory” from the excitement, inhibition of two aspects of the temporal lobe epilepsy mechanism. In recent years, studies have shown that moss-like fibers germinate granule cells increased excitability at the same time, post-synaptic GABA_A receptor also occurs functional changes, easily by the MF distal release Zn ~ (2 +) block, resulting in GABA inhibition decreased, which made the Mossy fiber germination / Zn2 + sensitivity GABA_A receptor mechanism has become a hot research field in academia.