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日本罔山大学医学部第一内科的研究小组,首次培养成功球状大鼠肝细胞。并利用其组成特殊循环培养装置,开发研制人工肝脏。研究人员将防止细胞在平面粘结的蛋白多糖物质涂在培养基上,从而将大鼠肝细胞培养成球状团块,100～200个肝细胞凝集起来直径为150～200μm。但是,由于这种凝集块彼此粘合即会因氧不足引起死亡。故用多糖体藻酸将其裹住,从而防止了粘合。
Japan’s Mountaine University Department of Medicine, the first medical research team, the first successful culture of rat spherical hepatocytes. And use its special cycle culture device, the development of artificial liver. Researchers will prevent the cells from coating the medium with planar gluco-proteoglycan material, so that the rat hepatocytes will be cultured into globular clumps, and 100 to 200 hepatocytes will agglomerate to 150-200 μm in diameter. However, due to the lack of oxygen, such agglutination blocks adhere to each other and cause death. Therefore, polysaccharides alginate wrapped it, thus preventing the adhesion.