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[目的]以C反应蛋白观察指标,探讨炎症反应在高血压发生、发展的作用及相互关系。[方法]按入选标准纳入高血压患者64人入试验组,门诊就诊的正常患者30人入对照组。将高血压组分为两个亚组:A组(无左室肥厚)37例,男21例,女16例;B组(伴左室肥厚)27例,男17例,女10例。比较试验组、对照组以及试验组各亚组间C反应蛋白水平差异。[结果]高血压两个亚组血清hsCRP浓度显著高于对照组(P﹤0.05);B组(伴左室肥厚)hsCRP浓度比A组(无左室肥厚)组高(P﹤0.05);血浆CRP水平与个体平均动脉压显著相关(P﹤0.01),血浆CRP水平越高,个体的血压值也越高。[结论]炎症在高血压的发生、维持与复发过程中起到了重要作用,CRP水平可以作为高血压病情评估的一个重要指标。
[Objective] To observe the index of C-reactive protein and explore the role and relationship of inflammatory reaction in the occurrence and development of hypertension. [Methods] According to the inclusion criteria, 64 hypertensive patients were enrolled into the experimental group and 30 outpatients were included in the control group. The hypertensive group was divided into two subgroups: group A (without left ventricular hypertrophy) 37 cases, 21 males and 16 females; group B (with left ventricular hypertrophy) 27 cases, 17 males and 10 females. The differences of C-reactive protein between the subgroups of the experimental group, the control group and the experimental group were compared. [Results] The serum hsCRP levels in two subgroups were significantly higher than those in control group (P <0.05). The hsCRP concentrations in group B (with left ventricular hypertrophy) were significantly higher than those in group A (without LVH) (P <0.05). Plasma CRP levels were significantly associated with mean arterial pressure (P <0.01). The higher the plasma CRP level, the higher the individual’s BP. [Conclusion] Inflammation plays an important role in the occurrence, maintenance and recurrence of hypertension. The level of CRP can be used as an important index to evaluate the condition of hypertension.