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在中国香港,母亲为HBeAg携带者所生婴儿,随机分成四个组。Ⅰ组在出生时及其1、2、6月接受3μg热灭活乙肝疫苗,7月接受HBIg注射液。Ⅱ组接种相同疫苗,但出生时仅接受一次HBIg注射。Ⅲ组在出生时及1、2、6月仅接受疫苗注射。Ⅳ组接受安慰剂。第一次接种应在出生后1小时内进行。实验结束时(495天),对140个至少6个月的儿童进行了比较,三个治疗组持续携带者的出现显著低于对照组(2.9％、6.8％
In Hong Kong, China, mothers were born to HBeAg-bearing babies and were randomly divided into four groups. Group Ⅰ received 3 μg heat-inactivated hepatitis B vaccine at birth and in January, February and June, and HBIg injection in July. Group II received the same vaccine but received HBIg only once at birth. Group Ⅲ was vaccinated only at birth and in January, June and June. Group IV received placebo. The first vaccination should be carried out within 1 hour after birth. At the end of the experiment (495 days), 140 children of at least 6 months were compared and the presence of sustained carriers in the three treatment groups was significantly lower than that in the control group (2.9%, 6.8%