目的:探讨丁苯酞联用丹参多酚酸注射液对大面积脑梗死患者的疗效及SOD酶的影响。方法:120例大面积脑梗死患者随机分为丁苯酞组、丹参多酚酸组和丁苯酞联用丹参多酚酸组,疗程均为2周,比较3组患者治疗后1周及治疗后2周的疗效,以及治疗前后Bathel指数评分、NIHSS评分及血中SOD酶含量的变化,记录3组药品不良反应发生情况。结果:丁苯酞联用丹参多酚酸组的有效率,明显高于丁苯酞组和丹参多酚酸组(P<0.05)。治疗后,3组患者的Bathel指数评分、NIHSS评分和SOD酶含量均较治疗前明显改善(P<0.05),且丁苯酞联用丹参多酚酸组均优于丁苯酞组与丹参多酚酸组(P<0.05)。3组药品不良反应发生率差异无统计学意义(P>0.05)。结论:丁苯酞联合丹参多酚注射液在治疗大面积脑梗死的疗效确切,值得在临床推广运用。 Objective: To investigate the efficacy of butylphthalide combined with Salviae miltiorrhiza polyphenols injection on patients with large area cerebral infarction and the effect of SOD enzyme. Methods: One hundred and twenty cases of large area cerebral infarction were randomly divided into butylphthalide group, Salviae miltiorrhizal polyphenolic acid group and Butylphthalide combined Salviae miltiorrhizae polyphenols group. The course of treatment was two weeks. The three groups were compared for one week after treatment and treatment After 2 weeks of treatment, as well as before and after treatment Bathel index score, NIHSS score and blood SOD enzyme content changes, record 3 groups of adverse drug reactions. Results: The effective rate of butylphthalide combined salvianolate group was significantly higher than that of butylphthalide group and salvianolate group (P <0.05). After treatment, Bathel index score, NIHSS score and SOD enzyme content were significantly improved in all three groups (P <0.05), and butylphthalide combined salvianolate group was superior to butylphthalide group and Salvia miltiorrhiza Phenolic acids group (P <0.05). There was no significant difference in the incidence of adverse drug reactions between the three groups (P> 0.05). Conclusion: Butylphthalide combined Salvia polyphenols injection in the treatment of large-area cerebral infarction is effective and worthy of clinical application.