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按GB15670—1995《农药登记毒理学试验方法》,低、中、高剂量染毒组动物分别予含200、800、3200mg/kg96%乙草胺原药的饲料喂饲90d,阴性对照组动物喂饲标准饲料。结果显示,高剂量组动物各周体重明显低于对照组,肝脏、肾脏脏器系数及该组雄鼠睾丸脏器系数明显高于对照组;中、低剂量组动物各项指标与对照组比较差异无统计学或生物学意义。提示乙草胺原药对动物体重增长有抑制作用,其靶器官可能是肝脏、肾脏;雌、雄大鼠亚慢性经口毒性试验最大无作用剂量分别为65.1、59.6mg/(kg·d)。
According to GB15670-1995 “Toxicological test of pesticide registration”, the animals in low, medium and high dose groups were fed with the feed containing 200,800,3200 mg / kg 96% acetochlor for 90 days, respectively. The negative control group animals were fed Feed standard feed. The results showed that the body weight of high dose group was significantly lower than that of the control group, the liver and kidney organ coefficient and the testis organ coefficient of the male group were significantly higher than those of the control group. The indexes of middle and low dose group were higher than those of the control group The difference was not statistically or biologically significant. It suggested that the original acetochlor inhibited the growth of animals and its target organ might be liver and kidney. The maximum non-action doses of subchronic oral toxicity test in female and male rats were 65.1 and 59.6 mg / (kg · d), respectively.