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目的研究ｒａｓｐ２１致癌基因和ＤＮＡ倍体与子宫颈癌及子宫内膜癌的关系。方法应用细胞免疫荧光技术和流式细胞术对４０例宫颈癌、２０例慢性宫颈炎、３２例子宫内膜癌和１３例癌前病变进行了ｒａｓｐ２１致癌基因的表达量及ＤＮＡ倍体的测定。结果子宫颈癌和子宫内膜癌ｒａｓｐ２１的表达量高于慢性宫颈炎和子宫内膜癌前病变，并与二者的组织学分级有关。ＤＮＡ倍体与ｒａｓｐ２１的表达量有关。结论ｒａｓｐ２１的表达与子宫颈癌和子宫内膜癌的发生有关。检测ｐ２１蛋白和ＤＮＡ倍体有助于判断这两种肿瘤的恶性程度和预后，并应积极治疗慢性宫颈炎
Objective To study the relationship between rasp21 oncogene and DNA ploidy and cervical cancer and endometrial cancer. Methods The expression of rasp21 oncogene and DNA ploidy in 40 cases of cervical cancer, 20 cases of chronic cervicitis, 32 cases of endometrial carcinoma and 13 cases of precancerous lesions were detected by immunofluorescence and flow cytometry. Results The expression of rasp21 in cervical cancer and endometrial carcinoma was higher than that in chronic cervicitis and endometrial precancerous lesions and was related to histological grade. DNA ploidy and rasp21 expression level. Conclusion The expression of rasp21 is associated with the development of cervical cancer and endometrial cancer. Detection of p21 protein and DNA ploidy will help determine the malignancy and prognosis of these two tumors, and should actively treat chronic cervicitis