毛细胞白血病最早由Bouroncle等人描述为一种临床疾病。它具有全血细胞减少、脾大,循环中出现“毛细胞”及所特有的病理表现。已有一些出现血管炎或多动脉炎样综合征的病例报道。作者报道1例最初有血管炎样病变、并伴有混合型冷球蛋白血症,继后发现有毛细胞白血病的男性病例。毛细胞白血病伴有冷球蛋白血症以前有1例报道,但是,病人虽有λ型IgG冷球蛋白而没有血管炎,就我们所知,这种毛细胞白血病,还是第一次报道。病例:男性,57岁。1981年7月就诊。3个月来食欲不振,体重减轻及全身皮肤病变。无出血、骨痛、发烧及黄疸。体检:四肢及躯干可见淤点、淤斑,肝脾肿大,无淋巴结肿大。实验室检查:红细胞比积22％,血小板 Hairy cell leukemia was first described by Bouroncle et al as a clinical disease. It has pancytopenia, splenomegaly, circulating “hair cells” and the unique pathological manifestations. There have been several cases of vasculitis or polyarteritis-like syndrome. The authors reported 1 patient initially having a vasculitic-like lesion with mixed cryoglobulinemia followed by a male case of hairy cell leukemia. Hair cell leukemia associated with cryoglobulinemia has been previously reported in 1 case, however, although the patient has lambda type IgG cryoglobulin without vasculitis, to our knowledge, this hairy cell leukemia, is the first time reported. Case: male, 57 years old. July 1981 treatment. 3 months to loss of appetite, weight loss and systemic skin lesions. No bleeding, bone pain, fever and jaundice. Physical examination: visible limbs and trunk bruising, ecchymosis, hepatosplenomegaly, no lymphadenopathy. Laboratory tests: 22% of hematocrit, platelets