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炎症反应对于心肌缺血再灌注损伤(MI/RI)过程的影响逐渐引起人们的重视,如何减轻炎症在MI/RI发生时对心肌的不良影响,已逐渐成为临床及基础研究的热点。目前研究发现,中药有效成分或中药复方通过减轻炎症细胞浸润、调控炎症相关细胞因子、减少黏附分子表达、抑制核转录因子活性等作用机制,在改善炎症损伤、拮抗炎症进展,从而减轻甚至消除MI/RI方面收效良好,显示出一定优势。故揭示中药防治MI/RI的科学内涵、阐明其药效物质基础成为今后研究中亟需解决的问题和努力的方向。
The impact of inflammatory response on the process of myocardial ischemia-reperfusion injury (MI / RI) has gradually attracted people’s attention. How to reduce the adverse effect of inflammation on myocardial during MI / RI has gradually become a hot spot in clinical and basic research. The current study found that active ingredients or traditional Chinese medicine compound by reducing inflammatory cell infiltration, regulating inflammation-related cytokines, reducing adhesion molecule expression, inhibition of nuclear transcription factor activity and other mechanisms of action in improving inflammation and injury, antagonizing the progress of inflammation, thereby reducing or even eliminating MI / RI aspects of effective, showing some advantages. Therefore revealing the scientific connotation of the prevention and cure MI / RI of traditional Chinese medicine and elucidating the substance basis of its efficacy have become the urgent problems to be solved in the future research and the direction of their efforts.