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研究Ｂｅｐｒｉｄｉｌ（Ｂｅｐ）的衍生物Ｔ１－２的抗心律失常及抗心肌梗塞作用．麻醉大鼠冠脉结扎再灌注诱发心律失常，记录心律失常分数，再行结扎３ｈ，取心肌ＴＴＣ染色测梗塞区．Ｔ１－２２．５，５ｍｇ／ｋｇ（ｉｐ）降低再灌注ＶＴ的发生率，分别降低了３６％（Ｐ＞０．０５），６２％（Ｐ＜０．０５），降低梗塞区范围，分别降低了２６％和４１％．所以Ｔ１－２具有与Ｂｅｐ相仿的抗心律失常及抗心肌缺血活性．
To study the anti-arrhythmia and anti-myocardial infarction effect of derivative T1-2 of Bepridil (Bep). Anesthetized rats were perfused with coronary artery ligation and reperfusion to induce arrhythmia. The arrhythmia score was recorded and then ligated for 3 hours. The myocardial infarction area was detected by TTC staining. T1-22.5,5mg / kg (ip) reduced the incidence of reperfusion VT by 36% (P> 0.05) and 62% (P <0.05) 26% and 41%. So T1-2 has anti-arrhythmia and anti-myocardial ischemic activity similar to Bep.