论文部分内容阅读
目的：研究碳酸钙片的相对生物利用度。方法：8名健康男性志愿受试者在口服碳酸钙片和磷酸氢钙片后的尿钙，以参数mg／mgCr和mg／LGF来评价钙的经肠吸收，并对试验数据进行统计分析。结果：口服2种制剂后0h～2h和2h～4h的尿钙增量无显著性差异（P＞0．05）;服药后4h尿钙的总排泄量及增量亦无显著性差异（P＞0．05）；以2种制剂服药后4h的尿钙总排泄量相比，碳酸钙片的相对生物利用度为（102．92±13．21）％。结论：碳酸钙片与磷酸氢钙片经口服后是生物等效制剂。
Objective: To study the relative bioavailability of calcium carbonate tablets. METHODS: Urinary calcium was measured in eight healthy male volunteers after oral administration of calcium carbonate tablets and calcium phosphate dibasic tablets, and the intestinal absorption of calcium was evaluated using the parameters mg / mgCr and mg / LGF, and statistical analyzes were performed on the experimental data. Results: There was no significant difference in urinary calcium excretion between 0h ~ 2h and 2h ~ 4h after oral administration of 2 kinds of drugs (P> 0.05) > 0.05). The relative bioavailability of calcium carbonate tablets was (102.92 ± 13.21)% when compared with the total urinary calcium excretion 4h after 2 kinds of preparations. CONCLUSION: Calcium carbonate tablets and calcium hydrogen phosphate tablets are bioequivalent after oral administration.