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目的 观察根除消化性溃疡伴幽门螺杆菌 (Hp)感染新方案的临床疗效。 方法 5 4例确诊消化性溃疡、Hp阳性患者 ,随机分为治疗组和对照组。治疗组 34例 ,予以雷贝拉唑 10mg/次 ,克拉霉素 0 5 g/次 ,阿莫西林 1 0g/次 ,均一日 2次 ,饭前一小时服用 ,连用 4天。对照组 2 0例 ,予以兰索拉唑 30mg/次 ,克拉霉素 0 5 g/次 ,阿莫西林 1 0g/次 ,均一日 2次 ,饭前一小时服用 ,连用 7天。疗程结束后 5～ 6周复查14 C尿素呼气试验 (14 C UBT)。计算两组患者用药成本及费用—效果比 (C/E)。结果 治疗组、对照组按治疗意向分析 (intentiontotreat,IT)的根除率分别为 82 35 % (2 8/34)、75 % (15 /2 0 ) ,按完成随访病例分析 (per protocol,PP)的根除率为 90 32 % (2 8/31)、88 2 4 % (15 /17)(P >0 0 5 ) ,副作用发生率为 12 9%、2 3 5 % ,C/E为 3 35、4 92。结论 含雷贝拉唑、克拉霉素、阿莫西林的三联 4日疗法 ,是一种短程、高效、更符合药物经济学要求的根除Hp方案。
Objective To observe the clinical efficacy of a new program for the eradication of peptic ulcer associated with Helicobacter pylori (Hp) infection. Methods Twenty-four patients with confirmed peptic ulcer and Hp positive were randomly divided into treatment group and control group. The treatment group 34 cases, to rabeprazole 10mg / times, clarithromycin 0 5 g / times, amoxicillin 10g / times, all day 2 times, an hour before meals, once every 4 days. The control group of 20 patients were given lansoprazole 30mg / times, clarithromycin 0 5 g / times, amoxicillin 10g / times, two times a day, taken an hour before meals, once every 7 days. The 14 C urea breath test (14 C UBT) was reviewed 5 to 6 weeks after the end of the course of treatment. The cost of medication and the cost-effectiveness ratio (C / E) were calculated for both groups. Results The eradication rates of intention-to-treat analysis (intentiontotreat, IT) in the treatment group and the control group were 82 35% (2/8/34) and 75% (15/2 0%), respectively. The eradication rates were 90 32% (2 8/31), 88 2 4% (15/17) (P 0 05). The incidence of side effects was 12 9%, 23 5% and the C / E was 35 , 4 92. Conclusion The triple therapy with rabeprazole, clarithromycin and amoxicillin is a short-term, high-efficiency and more eradication Hp program that meets the requirements of pharmacoeconomics.