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[目的]探讨全真一气汤对肾不纳气证模型大鼠血清ADM水平的影响。[方法]SO2熏吸+腺嘌呤饲料饲养复制肾不纳气证COPD大鼠模型。中药组用全真一气汤进行治疗,西药组用氨茶碱治疗,实验结束后测定大鼠血清中的肾上腺髓质素(ADM)含量。[结果]与西药组、模型组比较,中药组大鼠ADM含量升高(P<0.05或<0.01)。[结论]全真一气汤能够维持ADM水平,延缓COPD的进展,这是该方剂对COPD起效的治疗机制之一。
[Objective] To investigate the effect of Quanzhengyiqi Decoction on the level of serum ADM in rats with renal failure syndrome. [Method] SO2 smoked + adenine feed to reproduce rat model of COPD with renal non - The Chinese medicine group was treated with Quanzhen Yiqi Decoction, and the western medicine group was treated with aminophylline. The content of adrenomedullin (ADM) in rat serum was determined after the experiment. [Results] Compared with western medicine group and model group, the content of ADM in traditional Chinese medicine group increased (P <0.05 or <0.01). [Conclusion] Quanzhengyiqi Decoction can maintain the ADM level and delay the progress of COPD, which is one of the therapeutic mechanisms of this prescription on the onset of COPD.