Objective Primary malignant melanomas of the liver are exceedingly rare.Only 19 cases have been reported in the literature worldwide.In this report,we describe our pathological findings and review the literature in order to improve our understanding of the disease and prevent misdiagnosis,as well as provide evidence for its treatment and prognosis.Methods We present a case of an isolated malignant melanoma of the liver in a 61-year-old male Chinese patient.Results Comprehensive dermatological and ophthalmological examinations did not reveal any evidence of a primary cutaneous or ocular lesion.Similarly,serial physical examinations,auxiliary examinations,and bone scans did not demonstrate any other lesions in the brain,respiratory tract,and gastrointestinal tract.Microscopic examination of the resected specimen revealed malignant melanoma,which was confirmed by immunohistochemical staining for S-100 protein(+),ki67(30%+),EMA(+),CD10(+),and HMB-45(++).Conclusion Primary malignant melanoma may occur in the liver,and should be considered when the histopathological appearance is atypical of other hepatic neoplasms.The diagnostic criteria for hepatic malignant melanoma depend mainly on the clinical,radiographic,and histopathological findings.Pathomorphology and immumohistochemical staining can be utilized to confirm the diagnosis. Objective Primary malignant melanomas of the liver are exceedingly rare. Of 19 cases have been reported in the literature worldwide. In this report, we describe our pathological findings and review the literature in order to improve our understanding of the disease and prevent misdiagnosis, as well as provide evidence for its treatment and prognosis. Methods We present a case of an isolated malignant melanoma of the liver in a 61-year-old male Chinese. Results Comprehensive dermatological and ophthalmological examinations did not reveal any evidence of a primary cutaneous or ocular lesion.Similarly, serial physical examinations, auxiliary examinations, and bone scans did not demonstrate any other lesions in the brain, respiratory tract, and gastrointestinal tract. Microscopic examination of the resected specimen revealed malignant melanoma, which was confirmed by immunohistochemical staining for S- 100 protein (+), ki67 (30% +), EMA (+), CD10 (+), and HMB-45 a may occur in the liver, and should be considered when the histopathological appearance is atypical of other hepatic neoplasms. the diagnostic criteria for hepatic malignant melanoma depend mainly on the clinical, radiographic, and histopathological findings. Pathomorphology and immumohistochemical staining can be utilized to confirm the diagnosis.