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目的 :观察灌胃和静脉注射丁咯地尔对大鼠局部脑缺血的影响并比较国产和进口品的异同。方法 :采用电凝闭塞大脑中动脉引起局部脑梗塞 ,测其给药后行为和梗塞范围的大小以判断药物的作用。结果 :灌胃 2 5 ,5 0和 75mg/kg及静脉注射国产和进口丁咯地尔 3,6和 12mg/kg均能使电凝闭塞大脑中动脉引起的大鼠行为障碍明显减轻 ,脑梗塞范围 (以重量计 )明显缩小并呈剂量依赖关系。结论 :丁咯地尔具有明显的改善脑缺血引起的行为改变并有缩小脑梗塞范围的作用 ,国产和进口品之间无差异
Objective: To observe the effects of intragastric and intravenous buflomedil on focal cerebral ischemia in rats and compare the similarities and differences between domestic and imported products. Methods: The middle cerebral artery occlusion was induced by electrocoagulation occlusion, and the extent of the behavioral and infarct size was measured to determine the effect of the drug. Results: After intragastric administration of 25, 50 and 75 mg / kg intravenous budesonide and imported budesonide at 3, 6 and 12 mg / kg, the behavioral disorders of rats induced by electrocautery and occlusion of the middle cerebral artery were significantly reduced. Cerebral infarction The range (by weight) was significantly reduced and in a dose-dependent manner. CONCLUSION: Buflomedil can significantly improve the behavioral changes induced by cerebral ischemia and reduce the range of cerebral infarction. There is no difference between domestic and imported products