新生儿败血症指新生儿期细菌或真菌侵入血液循环并在其中生长繁殖产生毒素所造成的全身性感染。其发生率占活产婴儿的1‰~8‰,极低出生体重儿可达164‰,长期住院者可高达300‰[1]。尽管近年来在新生儿管理方面取得了重大进展,败血症仍是新生儿期危重症及造成死亡的重要原因。因此,临床早期诊断败血症并给予有效的抗生素治疗非常重要。但新生儿败血症发病隐匿,临床症状多为非特异性,血培养作为目前诊断新生儿败血症的 Neonatal sepsis refers to systemic infection caused by bacteria or fungi in the infancy that invade blood circulation and produce toxins in the body. Its incidence rate of 1 ‰ to 8 ‰ of live births, very low birth weight of up to 164 ‰, long-term residents can be as high as 300 ‰ [1]. Although significant progress has been made in neonatal management in recent years, sepsis remains an important cause of critically ill newborn infants and deaths. Therefore, early diagnosis of sepsis and effective antibiotic treatment is very important. However, the incidence of septic neonatal occult, mostly non-specific clinical symptoms, blood culture as the current diagnosis of neonatal sepsis