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Mecillinam(MPC)是6-β-脒基青霉酸衍生物。它通过优先与青霉素-结合蛋白2相结合而发挥其抗菌作用。结果在形成球状细菌细胞中其杀菌作用较其它抗生素更佳。本文旨在研究大肠杆菌产生的β-内酰胺酶是否足以导致对MPC耐药,以及不同的β-内酰胺酶是否对MPC耐药的影响亦不同。为了便于比较同时做了羟氨苄青霉素(AMPC)/克拉维酸(CV A)联用试验。用标准方法研究并鉴别产生TEM-1(RichmondⅢa型),Oxa-1(RichmondⅤ型)和染色体介导β-内酰胺酶(RichmondⅠ型)的大肠杆菌临床分离菌株,这些菌株均为最普遍的对氨苄青霉素族耐药(MIC大于64μg/ml)
Mecillinam (MPC) is a 6-beta-amidino penicillanic acid derivative. It exerts its antibacterial effect by preferentially binding to penicillin-binding protein 2. Results in the formation of spherical bacteria in the bactericidal effect than other antibiotics better. The aim of this article was to investigate whether β-lactamases produced by E. coli are sufficient to result in resistance to MPC and whether the effect of different β-lactamases on MPC resistance is different. For ease of comparison, amoxicillin (AMPC) / clavulanic acid (CVA) combination test was done at the same time. Strain E. coli isolates producing TEM-1 (Richmond type IIIa), Oxa-1 (Richmond type V) and chromosome-mediated β-lactamase (Richmond type I) were studied and identified by standard methods and these strains are the most common Ampicillin resistance (MIC> 64 μg / ml)