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钙拮抗剂又称钙通道阻滞剂和钙离子流抑制剂。近年来广泛用于心血管疾病并取得良好的疗效。本文简要综述钙拮抗剂的作用机理和临床应用。钙拮抗剂的作用机理按 Poole-Wilson的意见,钙拮抗剂的命名依据:①对心脏抑制作用可被钙逆转;②可防止用中毒量异丙基肾上腺素后心肌内钙的积聚;③抑制钙依赖的慢通道动作电位及肌张力;④选择性抑制心肌动作电位中的钙成分。其作用机理,Awan等:曾提到收缩组织兴奋和收缩的基本功能是依赖于各种离子,特别是钠、钾、钙的跨膜活动。钠钾离子对细胞的除极
Calcium antagonists, also known as calcium channel blockers and calcium ion current inhibitors. In recent years, widely used in cardiovascular disease and achieved good results. This article briefly reviews the mechanism and clinical application of calcium antagonists. Mechanism of action of calcium antagonists According to Poole-Wilson’s opinion, the name of calcium antagonists is based on the following: (1) cardiac inhibition can be reversed by calcium; (2) prevention of accumulation of intramyocardial calcium after poisoning with isoproterenol; (3) inhibition Calcium-dependent slow channel action potential and muscle tension; ④ selective inhibition of myocardial action potential in the calcium component. Its mechanism of action, Awan et al: Mentioned that the basic function of contraction and contraction of tissues is dependent on the transmembrane activity of various ions, especially sodium, potassium and calcium. Sodium potassium ions on the cell depolarization