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目的 了解纤溶活性和血、尿Ｄ－ 二聚体（Ｄ－ ｄ） 水平变化在高血压肾小动脉硬化症（ＨＡＮＳ） 中作用。方法 采用ＥＬＩＳＡ法测定血、尿Ｄ－ ｄ，用发色底物法测定纤溶酶（ｐ∶Ａ）、组织型纤溶酶原激活剂（ｔｐＡ∶Ａ） 及纤溶酶原抑制剂活性（ＰＡＩ∶Ａ） 。结果 原发性高血压（ＰＨ） 组及ＨＮＡＳ组较正常对照组，ｐ∶Ａ 和ｔｐＡ∶Ａ 明显降低，ＰＡＩ∶Ａ和血、尿Ｄ－ｄ 水平显著升高；ＨＮＡＳ组与ＰＨ 组比较，血浆ＰＡＩ∶Ａ 和尿Ｄ－ ｄ 水平差异显著。结论 纤溶活性和血、尿Ｄ－ 二聚体水平变化在高血压肾小动脉硬化的发生发展中具有重要作用
Objective To understand the role of fibrinolytic activity and blood-urine D-dimer (D-d) levels in hypertensive renal arteriosclerosis (HANS). Methods Serum and urinary D-d were measured by ELISA. The activities of plasminogen activator (pA), plasminogen activator (tpA: A) and plasminogen activator inhibitor-1 PAI: A). Results Compared with the normal control group, the levels of p:A and tpA:A in the patients with PH and HNAS were significantly decreased, while the levels of PAI:A and blood and urine D-d were significantly increased. Compared with PH group, Plasma PAI: A and urinary D-d levels were significantly different. Conclusion The changes of fibrinolytic activity and D-dimer levels in blood and urine play an important role in the development of hypertensive renal arteriosclerosis