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1894年 Von Eiselsberg 首先证实甲状腺恶性肿瘤具有内分泌活性。1937年尽管 Means 认为甲状腺毒症肯定可对抗甲状腺癌,但他却报道5例甲状腺机能亢进与甲状腺癌共存的病例。klein 报道甲状腺癌在弥漫性毒性甲状腺肿中的发生率为0～0.6%,在结节性毒性甲状隙肿中为0.8%～1.8%,Olen 报道两者共存者为2.5%,毒性甲状腺的冷结节中,甲状腺癌的发生率高达21.5%,这与正常甲状腺的冷结节中甲状腺癌发生率相同。然而甲状腺癌本身发生甲状腺机能亢进者极少,过去10年中由于广泛使用放射免疫检查法,已能诊断出亚临床性甲状腺机能亢进,这样,甲状腺癌伴甲状腺机能亢进的发生率可为3%～8%,而甲状腺术后发生转移性病变者为1.7%。
In 1894, Von Eiselsberg first confirmed the endocrine activity of thyroid malignancies. 1937 Despite Means that thyrotoxicosis certainly can fight thyroid cancer, but he reported 5 cases of hyperthyroidism and thyroid cancer coexistence cases. Klein reports that thyroid cancer is present in 0% to 0.6% of diffuse toxic goiter and 0.8% to 1.8% in nodular toxic goiter. Olen reports a coexistence of 2.5% with toxic thyroid cold In nodules, the incidence of thyroid cancer is as high as 21.5%, which is the same as the incidence of thyroid cancer in nodules with normal thyroid nodules. However, thyroid cancer itself is rarely hyperthyroidism, over the past 10 years due to the widespread use of radioimmunoassay, has been able to diagnose subclinical hyperthyroidism, so that the incidence of thyroid cancer with hyperthyroidism can be 3% ~ 8%, while the incidence of thyroid metastatic disease was 1.7%.