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目的:观察A型肉毒毒素治疗神经源性尿潴留的疗效,不良反应和有效时间。方法:收集21例神经疾病后尿潴留患者,A型肉毒毒素尿道外括约肌注射,记录治疗前后症状,尿流动力学指标,综合评估A型肉毒毒素治疗神经源性尿潴留的疗效,并记录不良反应和有效时间。结果:A型肉毒毒素治疗神经源性尿潴留,患者症状可明显改善,生存质量评分和国际下尿路综合征症状评分明显改善,尿流动力学指标明显改善,未见明显不良反应,疗效可维持(3±1)(1～5)个月。结论:A型肉毒毒素尿道外括约肌注射是一种治疗神经源性尿潴留的有效方法,短期内对部分患者能够显著改善排尿症状,提高生存质量,且未见不良反应。
Objective: To observe the efficacy, adverse reaction and effective time of botulinum neurotoxin A in the treatment of neurogenic urinary retention. Methods: Twenty-one patients with urinary retention after neurological disease were collected. The patients were given botulinum toxin type A external sphincter injection. The symptoms and urodynamics before and after treatment were recorded. The efficacy of botulinum neurotoxin A in the treatment of neurogenic urinary retention was recorded and recorded Adverse reactions and effective time. Results: Botulinum neurotoxin A treatment of neurogenic urinary retention, patients with symptoms can be significantly improved, quality of life scores and symptoms of lower urinary tract syndrome significantly improved, urodynamic indicators significantly improved, no significant adverse reactions, the effect can be Maintain (3 ± 1) (1 ~ 5) months. CONCLUSION: Botulinum toxin type A injection of the external urethral sphincter is an effective method for the treatment of neurogenic urinary retention. In short term, some patients can significantly improve urination symptoms and improve quality of life without adverse reactions.