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目的 了解癫患儿脑内代谢变化的特点。方法 应用Elscint2 .0T超导型磁共振仪 ,对 2 5例癫、5例难治性癫患儿脑内N 乙酰天门冬氨酸 (NAA)、肌酸和磷酸肌酸 (Cr)及含胆碱化合物 (Cho)的浓度进行测定 ,并以 10例非颅内疾病患儿作为对照。结果 癫组致灶内NAA及NAA/ (Cr+Cho)比值明显低于病灶对侧 (P <0 .0 1) ;难治性癫病程越长 ,临床发作次数越频繁 ,NAA/ (Cr+Cho)比值下降越明显 ,且 3例患儿乳酸 (Lac)含量明显升高。结论 神经元损伤或丢失可能是癫共同的病理特征 ;NAA/ (Cr+Cho)比值下降可能与病情程度相平行 ;与磁共振成像相比 ,磁共振波谱更能早期、敏感地反映惊厥后的脑损伤。
Objective To understand the characteristics of brain metabolism in epileptic children. Methods The Elscint 2.0T superconducting magnetic resonance imaging (MRS) was used to detect the levels of N-acetyl-aspartate (NAA), creatine and creatine phosphate (Cr) in 25 children with epilepsy and 5 children with refractory epilepsy Choline compounds (Cho) concentrations were measured, and 10 cases of non-intracranial disease in children as a control. Results The ratio of NAA and NAA / (Cr + Cho) in the epileptic group was significantly lower than that of the lesion (P <0.01). The longer the duration of refractory epilepsy was, the more the number of clinical seizures and the ratio of NAA / (Cr + Cho) decreased more significantly, and three cases of children with lactic acid (Lac) increased significantly. CONCLUSIONS: Neuronal injury or loss may be a common pathological feature of epilepsy. The decrease of NAA / (Cr + Cho) ratio may be parallel with the severity of illness. Compared with magnetic resonance imaging, magnetic resonance spectroscopy can reflect early and sensitive post-convulsive Brain damage.