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原发性胆汁性肝硬变(PBC)的病因还不清楚。仅知其与细胞及体液免疫异常有关。以前曾表明,PBC患者补体C3的降解明显增强以及单个核细胞的细胞粘附功能有损伤,并否认了该疾病与MHC相关。本文作者通过对PBC患者血液中与MHC连锁的补体成份C4(C4A及C4B)与B因子(Bf)的多态性检测,重新估价了MHC对PBC的影响。
The etiology of primary biliary cirrhosis (PBC) is unclear. Only know with the cell and humoral immune abnormalities. It has previously been shown that the markedly enhanced degradation of complement C3 in PBC patients and the impairment of the cell adhesion function of mononuclear cells, and denied that the disease is associated with MHC. The authors re-evaluated the effects of MHC on PBC by testing for the polymorphisms of the complement components C4 (C4A and C4B) and factor B (Bf) linked to MHC in the blood of PBC patients.