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本文作者采用分子杂交技术检测肝内HBV DNA,观察和分析干扰素治疗对肝内各种复制型病毒DNA的影响。 20例病人均为HBeAg阳性的慢性乙型肝炎,全部接受以重组技术制备的人白细胞干扰素治疗。按治疗剂量分成4组,第一组(6/20例)按常规剂量(36×10~6U/日),28天疗程;第二组(6/20例)予较大剂量(50×10~6U/日),28天疗程;第三组(6/20例)和第四组(2/20例)分别给予大剂量(72×10~6U/日和100×10~6U/日)治疗。于治疗前及治疗后第1、2周分别采集血和肝活
The authors used molecular hybridization to detect intrahepatic HBV DNA and observed and analyzed the effects of interferon treatment on various intrahepatic replicating viral DNA. All 20 patients were HBeAg-positive chronic hepatitis B, all of whom received human leukocyte interferon (IFN) therapy by recombinant technology. The patients in the first group (6/20 cases) were treated with the conventional dose (36 × 10 ~ 6 U / day) for 28 days and the second group (6/20 cases) ~ 6U / day) for 28 days. The third group (6/20 cases) and the fourth group (2/20 cases) were given high dose (72 × 10 ~ 6U / day and 100 × 10 ~ 6U / day) treatment. Blood and liver were harvested before and after the first and second week of treatment