目的探讨小剂量糖皮质激素佐治儿童大叶性肺炎支原体肺炎的临床疗效。方法选取2012年6月至2013年5月本科住院治疗的大叶性肺炎支原体肺炎患儿98例,其中观察组54例,对照组44例。两组患儿均予阿奇霉素加用阿莫西林克拉维酸钾、二代或三代头孢菌素治疗1~2周,观察组在此基础上加用甲泼尼龙1~2 mg/(kg·d),2~3 d后改口服泼尼松1~2 mg/(kg·d),泼尼松量不超过20 mg/d,而后每3 d减5 mg至停药。对比两组发热和咳嗽持续时间,并且治疗10 d复查胸片了解肺炎吸收情况评价治愈率。结果观察组患儿发热持续时间及咳嗽持续时间均短于对照组,差异有统计学意义(P<0.05);观察组治愈率(79.63%)明显高于对照组(65.91%),两组相比差异有统计学意义(P=0.000)。结论早期小剂量使用糖皮质激素佐治儿童大叶性肺炎支原体肺炎,能够较快缓解临床症状,缩短病程,提高治愈率。 Objective To investigate the clinical efficacy of low-dose glucocorticoids in treating children with lobar pneumonia mycoplasma pneumonia. Methods From June 2012 to May 2013, 98 children with Mycoplasma pneumoniae Mycoplasma pneumonia were admitted to our hospital, including 54 cases in observation group and 44 cases in control group. Two groups of children were treated with azithromycin plus amoxicillin and potassium clavulanate, second- or third-generation cephalosporins for 1 to 2 weeks. On the basis of this, the observation group was treated with methylprednisolone 1 ~ 2 mg / (kg · d ). After 2 ~ 3 days, oral prednisone was given 1 ~ 2 mg / (kg · d), prednisone did not exceed 20 mg / d, and every 5 days, 5 mg was withdrawn. The duration of fever and cough were compared between the two groups, and the chest radiographs were reviewed for 10 days to know the pneumonia absorption and evaluate the cure rate. Results The duration of fever and duration of cough in the observation group were shorter than those in the control group (P <0.05). The cure rate in the observation group (79.63%) was significantly higher than that in the control group (65.91%). The difference was statistically significant (P = 0.000). Conclusion Early low-dose glucocorticoid treatment of children with lobar pneumonia mycoplasma pneumonia, can quickly relieve clinical symptoms, shorten the course of disease and improve the cure rate.