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美国宾夕法尼亚州Hershey医学中心神经外科医师Waldemar将假单胞菌外毒素(PE)的受体结合区去除,与白细胞介素13(IL-13)结合.因为IL-13受体会在脑瘤中过度表达,所以由此产生的嵌合毒素对神经胶质瘤细胞有很强的亲和力.而全身毒性较小.在小鼠脑癌模型中,用这种方法作全身性治疗可使肿瘤消退,而直接肿瘤内注射可使肿瘤消失.Debinski的研究工作与John Wayne肿瘤研究所Rand所进行的研究相似.Rand计划修饰PE,使它对IL-4受体具有高度亲和力,而IL-4受体在肿瘤细胞上也有过度表达.Debinski说,他相信IL-13将证明是一种比IL-4更有效的导向工具.
Waldemar, a neurosurgeon at the Hershey Medical Center in Pennsylvania, USA, removes the receptor binding region of Pseudomonas exotoxin (PE) and binds to interleukin 13. (IL-13) Because IL-13 receptors are involved in brain tumors Overexpression, so the resulting chimeric toxin has a strong affinity for glioma cells, while less systemic toxicity in the mouse model of brain cancer, this method can be used for systemic treatment of tumor regression, While direct intratumoral injection can eliminate the tumor, Debinski’s work is similar to the one performed by John Wayne oncology Rand, who plans to modify PE to have a high affinity for IL-4 and IL-4 Dependent on tumor cells, Debinski said he believes IL-13 will prove to be a more effective targeting tool than IL-4.