硝异山梨酯(ISDN)为强效平滑肌松弛药,主要影响血管平滑肌。硝酸酯类化合物广泛应用于治疗心绞痛和充血性心力衰竭。有些研究集中于这类药物对动物和人的心血管作用,包括研究 ISDN 的血液动力学作用。ISDN 降低狗的冠脉血流和血压。ISDN降低人血压、右心房压和左心室充填压,然而没有数据说明 ISDN 对动物或人的大脑循环 Isosorbide-11 (ISDN) is a potent smooth muscle relaxant that affects mainly vascular smooth muscle. Nitrates are widely used in the treatment of angina pectoris and congestive heart failure. Some studies have focused on the cardiovascular effects of these drugs on animals and humans, including studies on the hemodynamic effects of ISDN. ISDN reduces coronary blood flow and blood pressure in dogs. ISDN decreases blood pressure, right atrial pressure and left ventricular filling pressure, however, there is no data on the circulation of the brain to animals or humans