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在大鼠皮肤移植模型上应用ＦＫ５０６并与ＣｓＡ作比较，以探讨其免疫抑制作用机理。实验结果表明：ＦＫ５０６组移植皮肤生长良好，完全存活率为７０．０５％，与ＣｓＡ相当；使用ＦＫ５０６２１ｄ后，ＦＫ５０６组脾细胞Ｉｌ－２及ｓＩｌ－２Ｒ的产生较对照组减少，且血中ｓＩｌ－２Ｒ较对照组低。证明ＦＫ５０６通过抑制Ｉｌ－２和Ｉｌ－２Ｒ及ｓＩｌ－２Ｒ的产生，从而发挥免疫抑制作用。
FK506 was applied to rat skin graft model and compared with CsA to explore its immunosuppressive mechanism. The experimental results showed that: the skin of FK506 group grew well with a complete survival rate of 70.05%, which was similar to that of CsA; the production of Il-2 and sIl-2R in spleen cells of FK506 group decreased compared with that of control group after FK50621d, -2R lower than the control group. It is demonstrated that FK506 exerts immunosuppressive effects by inhibiting the production of Il-2 and Il-2R and sIl-2R.