在内皮中,胰岛素刺激内皮型一氧化氮合酶(endothelial nitric oxide synthase,eNOS)以产生抗动脉粥样硬化信号的自由基——一氧化氮。2型糖尿病患者可利用的一氧化氮减少,导致动脉粥样硬化改变。内皮细胞胰岛素敏感性增加对一氧化氮合成的影响尚不清楚。为了回答这个问题,该研究使用Tie2启动子增强子构建内皮细胞特异性过表达人类胰岛素受体 In the endothelium, insulin stimulates endothelial nitric oxide synthase (eNOS) to produce free radical-nitric oxide, an anti-atherogenic signal. Patients with type 2 diabetes have fewer available nitric oxide, leading to changes in atherosclerosis. The effect of increased insulin sensitivity of endothelial cells on nitric oxide synthesis is not clear. To answer this question, the study used the Tie2 promoter enhancer to construct endothelial cells that specifically overexpress human insulin receptor