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目的 观察次声对肺的损伤作用及对动脉血氧分压 (PaO2 )和动脉血氧饱和度 (SaO2 )的影响。方法 将 30 0只SD大鼠随机分为正常对照组和次声作用 1次、3次、7次、14次、2 1次共 6组 ,次声作用组置本校研制的次声压力舱内致伤 ,以 8Hz和 16Hz次声 ,声压级分别为 90、10 0、110、12 0、130dB ,每次作用 2h。透射电镜下观察肺超微结构的改变 ,同时观察PaO2 和SaO2 的改变。结果 8Hz、90～ 110dB单次作用对肺部的超微结构基本无影响 ;8Hz、12 0～ 130dB作用后 ,肺组织形态学发生改变 ,而PaO2 和SaO2 无明显变化。 16Hz、90dB的次声单次作用 ,即可引起肺组织的损伤 ,随着声压级的增大 ,肺组织的影响程度更为明显 ;8Hz,12 0、130dB和 16Hz ,90、130dB的次声多次作用后 ,PaO2 和SaO2 明显下降 ,与正常对照组相比 ,差异有显著性 (P <0 .0 1)。在 3次、7次组其形态学的变化表现最为明显 ,随着作用次数的增加 ,其损伤并未继续加重 ,表现出适应性反应。结论 肺损伤的最小阈值 8Hz为 12 0dB ,16Hz为 90dB。即在一定作用强度范围内 ,可较明显地反映其频率作用的特性。次声损伤阈值的累积作用证明细胞发生变化的性质和程度主要与次声作用的声压强度和时间 (作用次数 )有关。
Objective To observe the effects of infrasound on lung injury and its effects on arterial oxygen saturation (PaO2) and arterial oxygen saturation (SaO2). Methods 30 0 SD rats were randomly divided into normal control group and infrasound acuity once, three times, seven times, 14 times and 21 times in total. Injured to 8Hz and 16Hz infrasound, sound pressure levels were 90,10 0,110,12 0,130 dB, each role 2h. The changes of lung ultrastructure were observed under transmission electron microscope, and the changes of PaO2 and SaO2 were also observed. Results A single dose of 8 Hz and 90 ~ 110 dB had no effect on the ultrastructure of the lungs. At 8 Hz and 120 ~ 130 dB, the morphological changes of the lungs were observed and the changes of PaO2 and SaO2 showed no significant changes. 16Hz, 90dB infrasound of a single role, can cause lung damage, with the sound pressure level increases, the extent of the lung tissue more obvious; 8Hz, 12 0,130 dB and 16Hz, 90,130dB times PaO2 and SaO2 decreased significantly after multiple times of sound, the difference was significant compared with the normal control group (P <0.01). In the 3rd and 7th groups, the morphological changes were the most obvious. With the increase of the number of times, the injury did not continue to aggravate and showed an adaptive response. Conclusions The minimum threshold for lung injury is 12 0 dB at 8 Hz and 90 dB at 16 Hz. That is, within a certain range of effect intensity, the characteristic of frequency effect can be more clearly reflected. The cumulative effect of infrasonic damage thresholds demonstrates that the nature and extent of cellular changes are primarily related to the sound pressure intensity and time of infrasound (number of effects).