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目的 调查幽门螺杆菌(Hp)感染与上消化道癌危险性的关系。方法 在江苏省淮安市和邳州市,应用HpIgG定量酶联免疫(ELISA)检测试剂盒,随机检测312例上消化道癌及其健康一级亲属对照人群外周血中抗HpIgG。结果 ①胃癌患者中HpIgG抗体水平(阳性率50.0%)高于贲门癌患者和食管癌患者(P>0.05,χ2检验);贲门癌患者与食管癌患者之间,以上三类癌症病例与其自身亲属对照之间,差异亦不明显;②胃癌组病例与亲属同时感染Hp的阳性率(27.1%)显著高于贲门癌组和食管癌组(P<0.05),后两组之间无明显差异。结论 Hp感染在胃癌家族中存在明显家庭聚集现象,Hp感染与胃癌危险性的关系有待进一步观察。
Objective To investigate the relationship between Helicobacter pylori (Hp) infection and the risk of upper gastrointestinal cancer. METHODS: HpIgG quantitative enzyme-linked immunosorbent assay (ELISA) kits were used in Huai’an City and Zhangzhou City, Jiangsu Province to detect the anti-HpIgG in peripheral blood of 312 patients with upper digestive tract cancer and their healthy first-degree relatives. Results 1 The level of HpIgG antibody in gastric cancer patients (positive rate 50.0%) was higher than that in patients with cardiac cancer and esophageal cancer (P>0.05, χ2 test); between patients with cardiac cancer and esophageal cancer, more than three types of cancer and their own relatives There was no significant difference between the controls.2 The positive rate of Hp infection in patients with gastric cancer and relatives (27.1%) was significantly higher than that in cardiac cancer and esophageal cancer (P<0.05). There was no significant difference between the two groups. Conclusion Hp infection has obvious family clustering in the gastric cancer family. The relationship between Hp infection and the risk of gastric cancer remains to be further observed.