抗黄体激素作用可通过以下四条途径:①阻碍孕酮的合成。②使血循环中孕酮失活。③拮抗孕酮受体。④雌激素对抗孕酮作用。其中与孕酮受体有亲和性,发挥拮抗作用的有RU486、丹那唑与gestrinone. 1.RU486:主要是与孕酮受体结合而发挥抗孕酮作用,其在体内的代谢产物结构上与炔诺酮相似,可能出现黄体激素与雄酮的作用,因此药效是 Anti-luteinizing hormone effect through the following four ways: ① hinder the synthesis of progesterone. ② in the blood circulation progesterone inactivation. ③ antagonize progesterone receptor. ④ estrogen against progesterone effect. Which has affinity with the progesterone receptor, play an antagonistic role RU486, Danazol and gestrinone. 1.RU486: Progesterone receptor binding and play an important role in anti-progesterone, its metabolites in the body structure Similar to norethindrone, luteinizing hormone and androsterone may appear, so the efficacy is