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使用多年的非肠道霍乱疫苗仅可提供50%的保护,而且保护仅可维持3—6个月。因此,目前的方法是发展经口服的新疫苗,提高保护性免疫原性,预防这种肠道疾病。理想的疫苗应符合以下要求,包括(1)高耐受性;(2)高保护性,可持续数年;(3)只需服用一剂;(4)几天内开始出现保护作用;(5)口服;(6)配方简单。减毒活霍乱菌苗株CVp 103-HgR似乎符合这一要求。
Parenteral cholera vaccines that have been used for many years provide only 50% protection, with protection for only 3-6 months. Therefore, the current approach is to develop new vaccines that are orally administered to increase protective immunogenicity and prevent this intestinal disease. The ideal vaccine should meet the following requirements, including (1) high tolerance; (2) high protective, sustainable for several years; (3) need only take one dose; (4) begin to show protection within a few days; 5) oral; (6) formula is simple. The attenuated live cholera vaccine strain CVp 103-HgR appears to meet this requirement.