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目的目前对兴奋性氨基酸（EAA）和抑制性氨基酸（IAA）的临床研究较少，从临床方面探讨EAA，IAA在脑梗塞发展过程中的作用可为今后临床深人研究提供一定的参考资料。方法应用高效液相色谱法对44例动脉粥样硬化性血栓性脑梗塞病人急性期和病后2周血浆EAA和IAA的含量进行测定，进行病人自身前后对照并与30例正常人对比。结果脑梗塞病人急性或血浆谷氨酸（Glu）、天门冬氨酸（Asp）、牛磷酸（Tau）含量明显高于正常对照组（P＜0.01）；病后2周其血浆含量有所下降，其中Glu含量与急性期相比有显著性差异（P＜0．01），但三者均未恢复正常，与正常对照组相比仍有显著性差异（P＜0．01）；血浆丙氨酸（Ala）、甘氨酸（Gly）在脑梗塞急性期及病后2周与正常对照组相比均无显著性差异（P＞0．05）。结论Glu、Asp作为损伤因素参与了脑梗塞的发生发展过程，研究EAA在脑梗塞中的作用时应同时观察IAA的相应变化．兴奋性毒性指数的概念值得进一步研究。测定血浆Glu的含量可考虑作为估计脑梗塞病程的一项生化指标。
Objective There are few clinical studies on excitatory amino acids (EAA) and inhibitory amino acids (IAA). To investigate the role of EAA and IAA in the development of cerebral infarction may provide some references for clinical research in the future. Methods The contents of plasma EAA and IAA in 44 patients with atherothrombotic cerebral infarction at acute and 2 weeks after operation were determined by HPLC. The patients were compared before and after their own control with 30 healthy controls. Results The levels of acute or plasma Glu, Asp and Tau in patients with cerebral infarction were significantly higher than those in normal controls (P <0.01) (P <0.01), but none of the three returned to normal, there is still significant difference compared with the normal control group (P <0.01); plasma C There was no significant difference between Ala and Gly in the acute phase of cerebral infarction and 2 weeks after the disease (P> 0.05). Conclusion Glu and Asp play an important role in the pathogenesis of cerebral infarction. To study the role of EAA in cerebral infarction, the corresponding changes of IAA should be observed. The concept of excitotoxicity deserves further study. Determination of plasma Glu content can be considered as a biochemical index to estimate the course of cerebral infarction.