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五氯酚可经过皮肤和呼吸道进入体内,经皮和经消化道的毒性已研究甚多,本文对尚未充分研究的呼吸道吸入途径的毒性进行了研究。实验动物为成年大白鼠,以经呼吸道吸入五氯酚钠气溶胶进行中毒实验。实验分一次吸入中毒和多次吸入中毒。一次吸人中毒为吸入五氯酚钠气溶胶20分钟;多次吸入中毒为每天吸入一次,每次20分钟,按连续吸入二次、三次、四次、五次四种情况分为四组。实验结束后各组动物在不同时间处死,对肺、肝、血液及尿液中五氯酚进行化验分析。
Pentachlorophenol can penetrate the skin and respiratory tract into the body, the toxicity of the percutaneous and the digestive tract have been studied in this paper, not yet fully studied the respiratory tract inhalation toxicity. The experimental animals were adult rats, which were exposed to sodium pentachlorophenol aerosol through the respiratory tract for poisoning experiments. Experimental points once inhaled poisoning and repeated inhalation poisoning. One inhalation poisoning inhaled sodium pentachlorophenol aerosol 20 minutes; multiple inhalation poisoning inhaled once a day, every 20 minutes, according to continuous inhalation of two, three, four, five times the four cases are divided into four groups. At the end of the experiment, each group of animals was sacrificed at different times, and PCP in lung, liver, blood and urine were tested.