论文部分内容阅读
目的探讨经湿化高流量鼻导管通气(HHFNC)治疗极低出生体重早产儿呼吸暂停的疗效。方法选取在本院产科出生并诊断为呼吸暂停的极低出生体重早产儿60例,随机分为HHFNC组(观察组)及对照组各30例。观察组在常规氨茶碱治疗基础上采用HHFNC,对照组仅采用常规氨茶碱治疗。结果与对照组比较,观察组总用氧时间(天)和无创通气时间(天)缩短[(12.8±4.9)比(19.2±7.0),(8.2±2.9)比(14.6±3.1)],频繁呼吸暂停发生率和因频繁呼吸暂停需重新辅助机械通气的比例降低[7/30(23.3%)比13/30(43.4%),10/30(33.3%)比17/30(56.7%)],鼻损伤发生率减少[1/30(3.3%)比9/30(30%)],差异均有统计学意义(P<0.01)。两组有创通气时间、坏死性小肠结肠炎发生率、喂养不耐受发生率差异无统计学意义(P>0.05)。结论 HHFNC联合氨茶碱比单纯氨茶碱治疗极低出生体重早产儿呼吸暂停更有效。
Objective To investigate the effect of humidified high flow nasal catheter ventilation (HHFNC) on apnea in very low birth weight preterm infants. Methods Sixty cases of very low birth weight preterm infants born in obstetrics department of our hospital and diagnosed as apnea were randomly divided into HHFNC group (observation group) and control group (n = 30). The observation group was treated with HHFNC on the basis of routine aminophylline treatment, while the control group was treated with conventional aminophylline only. Results Compared with the control group, the total duration of oxygen use (days) and noninvasive ventilation time (days) shortened (12.8 ± 4.9 vs. 19.2 ± 7.0, 8.2 ± 2.9, 14.6 ± 3.1, (7/30 (23.3%) vs 13/30 (43.4%), 10/30 (33.3%) vs 17/30 (56.7%)], and the rate of apnea and re-assisted mechanical ventilation due to frequent apneas were reduced , And the incidence of nasal injury was reduced [1/30 (3.3%) vs 9/30 (30%)]. The difference was statistically significant (P <0.01). There was no significant difference in the incidence of invasive ventilation, necrotizing enterocolitis and feeding intolerance between the two groups (P> 0.05). Conclusions HHFNC combined with aminophylline is more effective than aminophylline alone in treating apnea of very low birth weight preterm infants.