22例哮喘患儿(男10例,女12例;午龄5.1±2.8a)应用氨茶碱治疗,给药方式为口服法剂量4-5mg/(kg·次),或口服和直肠交替给药法,直肠给药剂量5-7mg/(kg·次),用药间隔均为6h。(?)用药后1.5h及5.5h分别测血药浓度,结果表明血药浓度与疗效和用药剂量密切相关。其中直肠给药法具有效果确切、方法简便及剂量可以按需掌握等优点。 Twenty-two asthmatic children (10 males and 12 females; 5.1 ± 2.8 years old) were treated with aminophylline by oral dose of 4-5 mg / (kg · d) or oral and rectal alternation Pharmacology, rectal dose of 5-7mg / (kg · times), medication interval of 6h. (?) 1.5h and 5.5h after treatment were measured blood concentration, the results show that the plasma concentration and efficacy and dosage are closely related. Which rectal administration has the exact effect, the method is simple and dose can be mastered on demand.