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目的:分析肝硬化好发胆囊结石的危险因素。方法:胆囊结石组194例,非胆囊结石组210例,彩超证实胆囊结石的存在,抽血检测血浆内毒素、低密度血浆脂蛋白-X(Lp-X),并进行Child-Pugh分级。结果:肝硬化胆囊结石组与肝硬化非胆囊结石组相比,两组在年龄、性别、饮酒史、血脂、血钙、Child-Pugh分级水平等方面无差异。胆囊结石组内毒素血症的发生率为82.99%,血浆内毒素水平为(74.97±69.76)pg/ml;非胆囊结石组内毒素血症的发生率为46.19%,血浆内毒素水平为(23.20±16.71)pg/ml,两组差异具有统计学意义(t=4.231,P<0.01;χ2=59.17,P<0.01)。低密度血浆脂蛋白-X阳性率也明显高于非胆囊结石组(χ2=21.28,P<0.01)。结论:内毒素血症与低密度血浆脂蛋白-X是肝硬化好发胆囊结石的重要危险因素。
Objective: To analyze the risk factors of gallstone in cirrhosis. Methods: One hundred and ninety-four cases of cholecystolithiasis and 210 cases of non-cholecystolithiasis were diagnosed by color Doppler ultrasonography. Plasma endotoxin and low density lipoprotein-L (Lp-X) were detected by color Doppler flow imaging and were graded by Child-Pugh. Results: There was no difference in age, sex, alcohol drinking history, serum lipids, serum calcium and Child-Pugh grading between the cirrhosis gallbladder group and the non-gallstone cirrhosis group. The incidence of endotoxemia in gallstone group was 82.99%, and the level of endotoxin in plasma was (74.97 ± 69.76) pg / ml. The incidence of endotoxemia in non-gallstone group was 46.19%, and the level of endotoxin in plasma was (23.20 ± 16.71) pg / ml, the difference between the two groups was statistically significant (t = 4.231, P <0.01; χ2 = 59.17, P <0.01). Low-density plasma lipoprotein-X positive rate was also significantly higher than non-gallstone group (χ2 = 21.28, P <0.01). Conclusion: Endotoxemia and low-density plasma lipoprotein-X are the important risk factors of gallstone in cirrhosis.