卵巢早衰(premature ovarian failure简称POF),过去亦有称为过早绝经(premature menopause)。近年来,称为高促性腺激素性闭经(hypergonadotropic amenorrhea)等。系指年龄小于40岁,伴有正常催乳素、高促性腺激素(FSH、LH)和低雌激素状态的闭经。这类病人中多因要求生育或出现绝经期症状而就诊,前者目前治疗上尚缺乏理想方法。本文旨在对我院近3年来92例诊断为POF病人的临床资料、内分泌检查、卵巢活检及其治疗进行分析和讨论。 Premature ovarian failure (POF), also known in the past as premature menopause. In recent years, known as hypergonadotropic amenorrhea (hypergonadotropic amenorrhea) and so on. Refers to amenorrhea less than 40 years of age with normal prolactin, high gonadotropin (FSH, LH) and low estrogen status. Most of these patients because of the requirement of childbearing or menopausal symptoms and treatment, the former is still the lack of treatment for the ideal method. The purpose of this paper is to analyze and discuss the clinical data, endocrine examination, ovarian biopsy and its treatment of 92 cases diagnosed as POF in our hospital in recent 3 years.