为了发现高效、低毒的农药先导化合物,以真菌几丁质为研究对象,以取代苯甲酸、5-取代苯基-2-呋喃甲醇为起始原料,设计合成了23个新型取代苯甲酰胺基硫代甲酸-(5-取代苯基-2-呋喃)-甲酯,其结构经IR,1H NMR和元素分析确证.初步生测结果表明,在50μg/mL浓度下,化合物对黄瓜褐斑菌、黄瓜灰霉菌、黄瓜枯萎菌表现出明显的防效,尤其对于黄瓜灰霉菌,大部分化合物的防效优于对照药剂40%菌核净WP. In order to find efficient and low toxic pesticide lead compounds, taking chitin of fungi as the research object and substituting benzoic acid and 5-substituted phenyl-2-furanmethanol as starting materials, 23 novel substituted benzamide The structures of the compounds were confirmed by IR, 1H NMR and elemental analysis. The results of preliminary bioassay showed that the compounds were sensitive to cucumber brown spots Botrytis cinerea, Botrytis cinerea, Fusarium oxysporum cucumber showed obvious control effect, especially for cucumber gray mold, the control effect of most of the compounds was better than that of 40% sclerotin of Control.