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136例高血压病患者按年龄分组,单次口服苯那普利10mg后,各年龄组收缩压和舒张压均明显下降,但50岁以上两组降压效果更显著,老年组(>60岁)有易出现体位性低血压趋势;基线血压及下降值与基线肾素活性水平无明显相关。结果说明苯那普利降压效果明显,不受年龄和血浆肾素活性影响。
136 patients with hypertension were grouped by age. After a single oral administration of benazepril 10 mg, the systolic and diastolic blood pressures were significantly decreased in all age groups, but the antihypertensive effects were more pronounced in those over 50 years old. The elderly group (> 60 years old ) Prone to orthostatic hypotension trends; baseline blood pressure and decreased values and baseline renin activity was no significant correlation. The results showed benazepril obvious antihypertensive effect, independent of age and plasma renin activity.