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目的描述我国1964-2009年文献报告的非围产期李斯特菌病的临床与流行病学特征,为李斯特菌病的防治提供科学依据。方法计算机检索与手工检索结合收集我国1964.1-2009.12非围产期李斯特菌病的文献报告资料,从中提取各非围产期李斯特菌病例的临床与流行病学信息并进行统计分析。结果共纳入66例非围产期李斯特菌病例,其中以男性、年龄>35岁者居多。患者的临床表现以CNS感染(42%)、败血症(41%)为主。免疫缺陷患者多表现为CNS感染,非免疫缺陷患者多表现为败血症。报告病例总死亡率为19%(11/57),其中免疫缺陷患者的死亡率高达28%(5/18)。结论我国非围产期李斯特菌病的临床特点与国外报告相符,报告死亡率与国外类似。
Objective To describe the clinical and epidemiological characteristics of non-perinatal listeriosis reported in the Chinese literature from 1964 to 2009, and provide a scientific basis for the prevention and treatment of listeriosis. Methods The computer-based retrieval and manual retrieval combined with the literature report of non-perinatal listeriosis from 1964.1-2009.12 in our country. The clinical and epidemiological information of each non-perinatal Listeria were extracted and statistically analyzed. Results A total of 66 cases of non-perinatal Listeria were enrolled, most of whom were men and were over 35 years old. The clinical manifestations of patients with CNS infection (42%), sepsis (41%) dominated. Patients with immunodeficiency often show CNS infection, and patients with non-immune deficiency often show sepsis. The overall reported case fatality rate was 19% (11/57), with immunodeficient mortality rates as high as 28% (5/18). Conclusion The clinical characteristics of non-perinatal Listeriosis are consistent with those of foreign reports, and the reported mortality rate is similar to that of foreign countries.