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本文目的是通过对14例呼吸道感染(Dose 300mg×2/d),10倒尿路感染病人(Dose 200mg×1/d),口服氟嗪酸片的药代动力学特性进行研究。血和尿中的氟嗪酸浓度测定用HPLC—离子对色谱荧光检测法。本法最小检测限0.03μmol/l,血和尿中平均回收率分别为96.8±5.9%和99.5±1.1%。呼吸道和尿路感染病人中氟嗓酸的药代动力学特性为一房室模型,其主要药代动力学参数为:t1/2 4.70±0.65h,5.25±0.75h;Vd 34.75±9.70l,38.20±15.70l;Cmax 7.85±3.35μmol/l(300mg×2/d),4.15±1.70μmol/1(200mg×1/d);t_(max)2.85±0.81h,1.44±1.04h;Clt 5.7±2.2 l/h,9.3±4.1 1/h。24h尿中氟嗪酸累积排出率分别为69.34±13.80,72.58±11.9%。
The purpose of this paper is to study the pharmacokinetics of oral fluorozine tablets in 14 patients with respiratory tract infection (Dose 300 mg × 2 / d) and 10 patients with inverted urinary tract infection (Dose 200 mg × 1 / d). Determination of flufenamic acid in blood and urine by HPLC-ion pair chromatography fluorescence detection method. The minimum detection limit of this method 0.03μmol / l, the average recovery of blood and urine were 96.8 ± 5.9% and 99.5 ± 1.1%. Pharmacokinetics of fluconic acid in patients with respiratory and urinary tract infections was a one-compartment model with major pharmacokinetic parameters: t1 / 2 4.70 ± 0.65h, 5.25 ± 0.75h; Vd 34.75 ± 9.70l, 38.20 ± 15.70 l; Cmax 7.85 ± 3.35 μmol / l (300 mg × 2 / d), 4.15 ± 1.70 μmol / l (200 mg × 1 / d); t max (max) 2.85 ± 0.81 h, 1.44 ± 1.04 h Clt 5.7 ± 2.2 l / h, 9.3 ± 4.1 1 / h. 24h urine urotropine cumulative discharge rates were 69.34 ± 13.80,72.58 ± 11.9%.