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目的：观察梭曼对心脏的直接作用，探讨梭曼中毒对动物心功能的损伤特点。方法：采用大鼠离体灌流心脏为模型，通过向心脏直接灌注梭曼，研究急性梭曼中毒后离体工作心脏功能的变化。结果：离体工作心脏灌注梭曼后，反应心脏收缩性能的指标如左心室内压（ＬＶＰ）、左室压上升最大速率（＋ｄｐ／ｄｔｍａｘ）、左室收缩成份的缩短速率（Ｖｃｅ－５０）等下降十分显著，而与心脏舒张功能有关的指标如左室舒张末压（ＬＶＥＤＰ）和左室压下降最大速率（－ｄｐ／ｄｔｍａｘ）等在中毒早期变化不明显。结论：梭曼对心脏的直接作用的关键环节可能是抑制心肌收缩性能，进而引起心脏整体功能降低
OBJECTIVE: To observe the direct effect of soman on the heart and to explore the characteristics of soman’s damage to heart function. Methods: The isolated perfused heart was used as a model to study the changes of isolated working heart function after acute soman poisoning by directly perfusing soman into the heart. Results: The left ventricular pressure (LVP), the maximum rate of left ventricular pressure (+ dp / dtmax) and the rate of shortening of left ventricular systolic component (Vce-50) , While the indexes related to diastolic function such as left ventricular end diastolic pressure (LVEDP) and maximal rate of left ventricular pressure descent (-dp / dtmax) did not change significantly at early stage of poisoning. CONCLUSIONS: The key aspect of soman’s direct action on the heart may be inhibition of myocardial contractility, which in turn leads to reduced overall cardiac function