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霉菌性脑膜炎或脑内病变常用静脉双氯苯咪唑或二性霉素B作为常规治疗,其治疗时间长,毒性大,合并症多。酮康唑(Ketoconazole)为新的口服咪唑类制剂,可有效地用于治疗脑膜外的各种霉菌感染,规定的有效剂量为200～400mg/天。由于该药安全,大剂量应用可达到有效的药物浓度而无明显副作用。作者研究了脑脊液中酮康唑的药物动力学,并观察了6例中枢神经系统霉菌感染患
Mycotic meningitis or brain lesions commonly used intravenous bischlorophenyl imidazole or amphotericin B as a routine treatment, the treatment of a long time, toxicity, complications and more. Ketoconazole is a new oral imidazole preparation that can be effectively used to treat various extracapsular fungal infections with the prescribed effective dose of 200-400 mg / day. Due to the safety of the drug, high-dose applications achieve effective drug concentrations without significant side effects. The authors studied the pharmacokinetics of ketoconazole in cerebrospinal fluid and observed 6 cases of fungal infection of the central nervous system