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目的：探讨大连市友谊医院血培养标本病原菌的分布特点和耐药性情况，为临床合理应用抗菌药物提供依据。方法回顾性分析我院2012年1月至2013年12月临床送检血培养标本的病原菌分布特征及耐药情况。结果1080套血培养标本中共分离出病原菌92株，阳性率为8.5%。革兰阳性菌48株，占52.2%；革兰阴性菌41株，占44.6%；真菌3株，占3.2%。革兰阳性菌对万古霉素和利奈唑胺高度敏感，革兰阴性菌对美洛培南高度敏感，其余抗生素均有不同程度的耐药。结论血培养标本检出的病原菌种类繁多，耐药情况较严重，临床应加强其耐药性的监测并合理应用抗菌药物。“,”Objective To explore the distribution characteristics and drug resistance of pathogens isolated from blood culture in dalian municipal friendship hospital in order to provide the basis for clinical rational use of antibiotics. Methods The retrospective statistical analysis method was performed on pathogens distribution and drug resistance.Pathogens were isolated from blood culture from 2012 January to 2013 December.Results A total of 92 strains of pathogens were isolated from 1080 sets of blood cul ture specimens with the positive rate of 8.5%.48 strains of which were Gram-positive bacteria(52.2%).41 strains of which were Gram-negative bacteria(44.6%).3 strains of which were fungi(3.2%).The Gram-positive bacteria were highly susceptible to vancomycin and linezolid, and the Gram-negative bacteria were highly susceptible to meropenem.Other antibiotics occurred resistance in some degree. Conclusion Many pathogens can be detected from blood cul ture specimens,and drug resistance is serious, Clinicians should strengthen the resistance monitoring of them and use the drug reasonably.