人类干细胞(human stem cell)虽然早在1998年已被分离出,但与胚胎干细胞功能相同的诱导多能干细胞(ips)的研究从21世纪2006年才开始发展。文章论述类似于胚胎干细胞的诱导多能干细胞研究应用进展。参阅近3年来文献,对用实验小鼠成纤维细胞、成人体细胞及普通人皮肤以及病人的特异性细胞以4个基因诱导产生诱导多能干细胞研究应用的最新进展进行了综述。诱导多能干细胞的应用将为各类严重疾病的治疗开拓广阔的应用前景。 Although human stem cells have been isolated as early as 1998, the study on inducing pluripotent stem cells (ips), which has the same function as embryonic stem cells, started its development in the 21st century in 2006. The article discusses the application of embryonic stem cell-induced pluripotent stem cell research. Based on the literature of the past three years, recent advances in the research of induced pluripotent stem cells induced by four genes in experimental mouse fibroblasts, adult somatic cells and common human skin and patient-specific cells are reviewed. The application of induced pluripotent stem cells will open up broad application prospects for the treatment of various serious diseases.